Nkhani

Mbiri Yolowetsedwa Kwambiri

Kulowetsedwa kozungulira (Tci) Ndi njira yothetsera mankhwala osokoneza bongo kuti mukwaniritse zonenedwa ("chandamale") mankhwala osokoneza bongo omwe ali ndi chidwi. Powunikiraku, timalongosola mfundo za pharmacokinetic za Tci, kukula kwa tci kachitidwe ka tci, ndi nkhani zaukadaulo komanso zowongolera zomwe zalembedwa mu prototype chitukuko. Timalongosolanso kukhazikitsidwa kwa njira zomwe zilipo.

Cholinga cha mtundu uliwonse wa zowonjezera za mankhwala ndi kukwaniritsa nthawi yochizira komanso kupewa matenda osokoneza bongo, popewa mavuto. Mankhwala osokoneza bongo nthawi zambiri amaperekedwa pogwiritsa ntchito malangizo oyendetsa. Nthawi zambiri wodwala yekhayo amene amaphatikizidwa ndi mlingo ndi ma metric a kukula kwa odwala, nthawi zambiri amalemera iv mankhwala othandizira. Makhalidwe odekha monga azaka, zogonana, kapena chilolezo cha creatinine nthawi zambiri sichimaphatikizidwa chifukwa cha zovuta za masamu azomwezi. M'mbuyomu pakhala njira ziwiri zoperekera mankhwala osokoneza bongo panthawi ya opaleshoni: Mlingo wa Bolus ndi kulowetsedwa kosalekeza. Mlingo wa Bolus umaperekedwa ndi syringe. Kukonda kumaperekedwa ndi kupatuka kulowetsedwa.

Mankhwala aliwonse okongoletsa amadziunjikira minofu pobweretsa mankhwala osokoneza bongo. Kuchulukitsa kumeneku kumasokoneza ubale pakati pa kulowetsedwa kwa chipatala ndi mankhwala osokoneza bongo. Kuchuluka kwa mawonekedwe a 100 μg / kg / mphindi kumalumikizidwa ndi odwala pafupifupi mphindi 3 kulowa ndikugona kwambiri kapena kugona. Pogwiritsa ntchito mankhwala odziwika bwino (pk), makompyuta amatha kudziwa kuchuluka kwa mankhwala omwe apezeka mu minofu mu infrisions ndipo amatha kusintha kulowetsedwa kwamphamvu kuti azikhala ndi chidwi chokhala ndi kachilomboka, makamaka ubongo. Kompyutayo imatha kugwiritsa ntchito mtundu wabwino kwambiri kuchokera m'mabuku, chifukwa kusinthasintha kwa masamu kuti muphatikizire mikhalidwe ya odwala (kulemera, ndi zowonjezera zazomwe zimapangidwa ndi makompyuta) Ndi tci kachitidwe ka Tci, chipatalachi chimalowa chidwi cha chandamale. Kompyutayo imawerengera kuchuluka kwa mankhwalawa, operekedwa ngati boloses ndi infusions, amafunikira kukwaniritsa zomwe akufuna kutsata ndikuwongolera polowetsedwa ndi bolus yowerengera kapena kulowetsedwa. Kompyuta nthawi zonse imawerengera kuchuluka kwa mankhwalawo komanso momwe zimathandizira kuchuluka kwa mankhwala ofunikira kuti akwaniritse cholinga cha PKS omwe amasankhidwa ndi wodwalayo.

Pa opaleshoni, kuchuluka kwa zojambulajambula kumatha kusintha mwachangu, kufunikira koyenera, kulowetsa kwa mankhwalawa mwachangu kwa mankhwala osokoneza bongo. Infafusion yosakhazikika silingakulitse mankhwala osokoneza bongo okwanira ku akaunti yowonjezera pakukongoletsa kapena kutsika kwamphamvu mofulumira kuwerengera kosangalatsa. Kudzikuza kwachilengedwe sikungasunge mankhwala osokoneza bongo muulalo kapena ubongo nthawi zonse. Pophatikizira mitundu ya PK, TCI Systems imatha kuyankha mwatete ngati kofunikira komanso mofananamo mosalekeza. Kupindulitsa kwa zipatala ndi lamulo lolondola la mankhwala osokoneza bongo a mankhwala osokoneza bongo.3

Powunikiraku, timafotokoza za PK za Tci, kukula kwa tci kachitidwe ka tci, ndi nkhani zamaukadaulo komanso zowongolera zomwe zalembedwa mu prototype chitukuko. Zolemba ziwiri zophatikizira zowunikira zomwe zikuchitika padziko lonse lapansi komanso nkhani zachitetezo zokhudzana ndi ukadaulo uwu.4,5

Pamene TCI Systems imasinthidwa, ofufuza adasankha mawu a Idiosyncratic for njira. Makina a TCI adatchedwa kuti pakompyuta ya IV AVPHLIA (Camia), Thumba), Pamporms Officence Office (CACI) kuti mawu a TCI amatengedwa ngati malongosoledwe a ukadaulo a ukadaulo.10