Nkhani

Mu 1968, Kruger-Theimer adawonetsa momwe mitundu ya pharmacokinetic ingagwiritsire ntchito kupanga ma regimens abwino a mlingo. Regimen iyi ya Bolus, Elimination, Transfer (BET) ili ndi:

mlingo wa bolus wowerengedwa kudzaza chipinda chapakati (mwazi),

kulowetsedwa kosalekeza kofanana ndi kuchuluka kwa kuchotsa,

kulowetsedwa komwe kumalipiritsa kusamutsidwa kuzinthu zotumphukira: [kuchepa kwakukulu]

Chizoloŵezi chachikhalidwe chimaphatikizapo kuwerengera ndondomeko ya kulowetsedwa kwa propofol ndi njira ya Roberts. Mlingo wotsitsa wa 1.5 mg / kg umatsatiridwa ndi kulowetsedwa kwa 10 mg / kg / ola komwe kumachepetsedwa kukhala mitengo ya 8 ndi 6 mg / kg / ora pakadutsa mphindi khumi.

Kutsata kwa tsamba

Zotsatira zazikulu zamankhwala oletsa ululuMtsempha wa mtsempha ndi sedative ndi hypnotic zotsatira ndipo malo omwe mankhwalawa amachitira izi, amatchedwa malo okhudzidwa ndi ubongo. Tsoka ilo sizotheka m'zachipatala kuyeza kuchuluka kwaubongo [malo ochita]. Ngakhale titha kuyeza kukhazikika kwaubongo, kungakhale kofunikira kudziwa madera enieni kapena ma receptor omwe mankhwalawo amachita.

Kupeza nthawi zonse propofol ndende

Chithunzi chomwe chili m'munsichi chikuwonetsa kuchuluka kwa kulowetsedwa komwe kumafunika kutsika kwambiri pambuyo pa mlingo wa bolus kuti magazi a propofol asasunthike. Zimawonetsanso kutsalira pakati pa magazi ndi zotsatira za malo.