Nkhani

Mu 1968, Krurger-Therimer Valiyoni momwe mar prmacokinetic amagwiritsidwira ntchito popanga maulamuliro othandiza a mlingo. Bolus iyi, kuchotsedwa, kusamutsa (kubetcha) Regimen ali:

Mlingo wa Bolus umawerengedwa kuti uzaze chipinda chapakati (magazi),

kulowetsedwa kosalekeza kufanana ndi kuchuluka kochotsa,

kulowetsedwa komwe kumathandizira kusamutsidwa ku minyewa yazokhazikika: [Kuchepetsa pang'ono pang'ono]

Zochitika zachikhalidwe zomwe zimaphatikizapo kuwerengera kulowetsedwa kwa propofol njira ya Roberts. Mlingo wa 1.5 mg / kg / kg / kg / kg / kg / kg / kg / ora omwe amachepetsedwa kwa 8 ndi 6 mg / kg / rr pa nthawi khumi.

Zotsatira zatsamba

Zoyambitsa zazikulu zamankhalaOthandizira amtunduwu ndi zovuta komanso zoopsa komanso tsamba lomwe mankhwalawa amafalitsa magazini ndi ubongo. Tsoka ilo sizotheka kuti muyesetse muubongo [tsamba]. Ngakhale titayeza ubongo mwachindunji, zingakhale zofunikira kudziwa kuchuluka kwa chigawo kapena ngakhale mukugwiritsa ntchito mankhwala omwe mankhwalawa amathandiza.

Kukwaniritsa zomwe zikuchitika mosalekeza

Chojambula chomwe chili pansipa chikuwonetsa kusintha kwa kulowetsedwa komwe kumafunikira pakuchepetsa kwamphamvu pambuyo pa mpweya wa bolus kuti mukhalebe ndi vuto la propofol. Zimawonetsanso cholowera pakati pa magazi ndi kusintha kwa zotsatira.